Modifications in glomerular polyanion distribution in adriamycin nephrosis.
نویسندگان
چکیده
منابع مشابه
Modifications in glomerular polyanion distribution in adriamycin nephrosis.
Previous reports have suggested that, in proteinuria induced by adriamycin (ADR), the functional size barrier of the glomerular basement membrane (GBM) is altered as the result of a sieving defect, whereas the functional charge barrier of the glomeruli remains intact. The aim of this study was to reevaluate the effect of ADR on anionic constituents in the glomerular capillary wall (GCW). Kidney...
متن کاملVascular dysfunction in adriamycin nephrosis: different effects of adriamycin exposure and nephrosis.
BACKGROUND Nephrosis-induced endothelial dysfunction is assumed to play a main role in cardiovascular morbidity. Adriamycin-induced proteinuria is a well-established rat model for nephrotic syndrome. However, induction of nephrosis by intravenous adriamycin administration might exert direct adriamycin cardiovasculotoxicity that could obscure or modify nephrosis-induced vascular dysfunction. The...
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چکیده رساله/پایان نامه : تاکنون روشهای متعددی در ارتباط با مکان یابی خطا در شبکه انتقال ارائه شده است. استفاده مستقیم از این روشها در شبکه توزیع به دلایلی همچون وجود انشعابهای متعدد، غیر یکنواختی فیدرها (خطوط کابلی، خطوط هوایی، سطح مقطع متفاوت انشعاب ها و تنه اصلی فیدر)، نامتعادلی (عدم جابجا شدگی خطوط، بارهای تکفاز و سه فاز)، ثابت نبودن بار و اندازه گیری مقادیر ولتاژ و جریان فقط در ابتدای...
Renal purine efflux and xanthine oxidase activity during experimental nephrosis in rats: difference between puromycin aminonucleoside and adriamycin nephrosis.
1. The hypothesis was tested that the renal xanthine oxidase system provides a source of oxygen free radicals in puromycin aminonucleoside and adriamycin experimental nephrosis by generating uric acid from hypoxanthine and xanthine. 2. The concentrations in renal tissue of the putative intermediary products of puromycin aminonucleoside metabolism, hypoxanthine and xanthine, and of their precurs...
متن کاملAdriamycin alters glomerular endothelium to induce proteinuria.
The pathophysiology underlying the nephrotic syndrome is becoming clear for several inherited podocytopathies; the mechanisms of injury that lead to the acquired forms of this disease are not well understood. We explored these mechanisms using the mouse model of adriamycin-induced proteinuria.We estimated the fractional clearances for FITC-Ficolls, albumin, and neutral albumin in cooled, isolat...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 1995
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.v5101799